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Holistic Therapies for ASD: What the Research Says

Dr. Genevieve Newton is joined by Rita Mastrangelo, a certified functional nutrition health coach, FDN practitioner, and founder of Purely Functional Nutrition — and a mom who navigated her son Jordan's autism diagnosis at age 2.5. Rita shares how functional lab testing (organic acids, stool, total toxin panels, mineral analysis) revealed the root-cause picture that conventional care missed: candida and mold colonization, gut dysbiosis, mitochondrial dysfunction, and a SOD2 genetic variant driving oxidative stress. This is a deeply practical episode about what functional investigation of ASD can look like.

The second half of the conversation turns to red light therapy and its emerging role in autism support. Dr. Gen reviews four published studies including a controlled trial showing measurable EEG changes and reduced autism severity scores following photobiomodulation. Rita describes implementing a protocol with Jordan — starting at 5 minutes, 50% intensity, and gradually working up to 20 minutes — alternating sessions between the head wrap and abdominal application to address both neurological and gut-related symptoms. The gut-brain axis is central to everything here: heal the gut, and the brain often responds.

The episode covers the Fringe transcranial head wrap (combining red, 850nm NIR, and 1050nm NIR light), the rationale for alternating head and gut protocol days, LED versus laser considerations, and how to approach this work as a complement to — not a replacement for — other evidence-based interventions. For families navigating ASD, this episode offers both hope and a framework.

 

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Transcript

Genevieve: Hey everyone, welcome back to the Fringe podcast. I am Dr. Genevieve Newton, Scientific Director at Fringe. Today I'm here with Rita Mastrangelo from Purely Functional Nutrition. We're here to talk about holistic therapies for autism. I'll be coming at things from the perspective of red light therapy. Rita will share her extensive knowledge about autism as it relates to functional nutritional medicine. She comes at this personally — she's the mum to a 15-year-old son named Jordan, who was diagnosed with autism at age two and a half. Through some very challenging experiences, she was led to explore this entire complex world of functional nutrition. Rita has become a certified functional nutrition health coach and functional diagnostic nutrition practitioner. She started Purely Functional Nutrition, which helps families who have children with autism using nutritional and functional lab testing to expose those hidden stressors — the things that are really the root of autism. She works with clients using lifestyle, nutrition, and supplements to improve health. Rita, thank you for being here. When you have a new family come in to see you, can you talk us through the diagnostic process? What are you looking for and how do you find it?

Rita: My practice is virtual. When I speak with families — typically moms — it's over Zoom. The world of autism is very complex. I'm not looking at the diagnosis because many children diagnosed with autism have behavioral issues that contribute to their autism diagnosis at a purely behavioral level. The first thing I focus on is really understanding what the child is going through. I look at patterns. What is the child currently eating? Is the child a picky eater? How is their digestion? Are they constipated? What does their poop look like? How are they sleeping? Do they sleep through the night? Do they wake up in the middle of the night? How are they behaving at home? All of those behaviors are really going to tell me where the body is struggling. From there, we start with the foundations: nutrition. Many children are picky eaters so we start building food variety — I call it stealth nutrition. I look at what the child is currently eating and see how I can incorporate nutrient-dense foods into those foods, without compromising taste or smell. Then lifestyle. Then I rely on functional lab tests, which give me a clear picture of what might be contributing to the dysfunction and imbalances going on in the body. Nothing can really replace lab testing — no intake form, no checklist provides the accurate information that functional lab tests do. With a child who has a complex diagnosis, there's going to be a lot of elevations, but it doesn't leave me guessing as to where the dysfunction is. Understanding their nutrition, their lifestyle, and getting those markers allows me to provide an individualized roadmap. There's not one protocol that's for every child.

Genevieve: It sounds like there are layers — you're seeing what's going on at the lifestyle and nutritional level, and then using functional lab testing to validate what you already suspect. What are some of the tests you run, and what sort of results do you typically see?

Rita: There isn't just one functional lab test that will give you all the information. I run four: an organic acid test, a stool test, a total toxin test, and a mineral test. Each test gives me great information but I need the others to complement them. I don't treat the paper — I connect the dots and correlate with the behaviors of the child. But every child's lab results have imbalances. I would say 99% of the children have mold colonization in their gut, Candida overgrowth, bacterial imbalances, mitochondrial dysfunction, methylation issues, neurotransmitter issues. When it comes to gut health: many have low bacterial diversity, poor digestion, overgrowth of opportunistic bacteria because they're not eating a nutrient-dense, fiber-rich diet. These children are picky eaters — they're not eating those foundational foods that support optimal gut health at a cellular level. I often see the body under stress, which shows up as nutrient imbalances and oxidative stress. Because of that imbalanced gut, it impacts the gut-brain connection. If you have inflammation, that information isn't going to get to the brain efficiently. What happens in the gut doesn't stay in the gut. The resilience of the gut really influences how the brain functions — that's when we see the behavior, mood, and dysregulation. I also see a lot of environmental contributors: where there's mold, there are mycotoxins. There's also a lot of heavy metals. Our body has no use for heavy metals, but they cause a lot of neural inflammation. The organic acid test is one of my favorites — it's a urine test that looks at metabolites. I explain it as: we're not looking at the fire, we're looking at the smoke. There are a lot of patterns on the organic acid test that suggest mitochondrial strain or mitochondrial dysfunction. That helps me understand how well the body is producing energy at a cellular level.

Genevieve: Could you give an example using Jordan of a test result you would see that you could map onto a specific behavior?

Rita: Arabinose is a marker on the organic acid test — it's a metabolite of Candida overgrowth. We all have Candida; it's when it becomes opportunistic that it causes a lot of behaviors. Children with Candida overgrowth will often show signs of aggression, inappropriate behavior, giddiness, even pressing on their genital area — not because of pleasure but because of that deep pressure the body is seeking. There are also the mitochondrial markers, the Krebs cycle metabolites, that tell me the body is going through some type of stress. With Jordan, he always had two markers that were elevated — methylglutaric and hydroxyglutaric — which is indicative of mitochondrial stress. Jordan always ate well, but it was like: why are these markers always elevated? Why is he always rigid and stressed even when he speaks?

Genevieve: So there's a dysfunction at the level of the mitochondria that's most likely happening at a genetic level. With the Candida, I'm also thinking you'd see a craving for sugar — a positive reinforcement cycle where they crave more sugar, eat more sugar, the Candida gets worse, and the behavior worsens as well.

Rita: Yes, absolutely. Candida thrives off of sugar. A lot of families are always told to kill the Candida. Either they kill it and the behavior subsides but comes back, or the Candida marker is no longer elevated but their child still experiences the behavior. Candida is not the problem — it's a result of the problem. It's become opportunistic because of something else. As an FDN, we're taught to always dig deeper. What can be contributing to Candida overgrowth? Dysbiosis, gut issues, heavy metals, parasites, H. pylori, low copper, not eating a balanced diet — we always have to understand what's causing the environment to be opportunistic. It's never one thing. It's never about killing. It's always about healing opportunities. Even if a child has significant amounts of opportunistic bacteria on their stool test, it's not a matter of killing the opportunistic bacteria but rather increasing the commensal bacteria.

Genevieve: It sounds like you have to keep digging deeper and deeper. What you described with Jordan's markers is different — you're essentially uncovering something at the most foundational level of mitochondrial function. Did you do any genetic testing to uncover polymorphisms?

Rita: That's not one of the tests I start with right away because any elevation on the functional lab tests — we always try to bring balance back by building resilience in the gut, restoring what's missing in the gut to function optimally. When you start focusing on building balance back in the gut microbiome, everything kind of starts to settle down on its own. For Jordan, what I always found was that every time I would retest, he would always have mitochondrial markers elevated. When we continued running the organic acid tests, we consistently saw the methylglutaric and hydroxyglutaric elevated. One of my mentors recommended we run a mito swab for Jordan, which would look more directly at how the electron transport chain was functioning. That test found that complex one wasn't working efficiently, and there were inefficiencies in complex two and three. Which confirmed that his cells were under strain. I had run genetic testing on Jordan years prior and he has multiple genetic variants — one of them was the SOD2 variant, which affects how the body handles oxidative stress at a mitochondrial level. When you put all that together, it really painted a picture of mitochondrial stress and an increased oxidative load. We also did plasmalogen testing and his plasmalogens, the white matter, were very low. From a cellular and mitochondrial membrane level, he was struggling. That's when we started adding targeted support to help rebuild those levels. And that's when we were introduced to red light therapy.

Genevieve: Right — as a non-dietary or non-pharmacological intervention to help support mitochondrial function. We so often use the term mitochondrial dysfunction in relation to autism spectrum disorders and ADHD. But you don't necessarily see what is actually causing that mitochondrial dysfunction. You mentioned three complexes in the electron transport chain were affected. For those listening who remember grade 11 biology — the electron transport chain has four complexes and is an essential, complicated part of our physiology. This is where red light therapy comes in: it supports the production of cellular energy specifically through effects on complex four. What have been your experiences using red light therapy to support mitochondrial dysfunction?

Rita: Jordan used to stutter a lot and that's when I would notice something was going on. When a child is diagnosed with autism, there are so many complex issues going on. But when we start bringing balance back, a lot of children who have an autism diagnosis get better — the diagnosis gets removed. And then you have other children like Jordan, who doesn't have those same imbalances but is a neurodivergent individual who's just different — thinking and behaving differently than a neurotypical kid. For me, what I really needed to focus on was how to help Jordan gain that calm in his body that he's lacking. We started with the Tri-light panel — a small one we put on his lower back and the back of his head. Then it was recommended to me from a chiropractor colleague that Jordan would benefit from one specifically over the head. That's when I connected with Fringe, because Fringe offers a full head wrap that allows more coverage across the brain.

Genevieve: The goal is to get light to the cells and tissues. When we're talking about somebody who has autism, the main target we want to get the light to is the brain. There's some evidence that delivering light to other parts of the body — the lower back, back of the head — has also been found to be beneficial. But for the most convenient, easiest delivery, especially for a child or teenager, it's helpful to have something that fits comfortably and is portable and wireless, so you can walk around while you use it. That's why we designed our head wrap the way we did. When we talk about red light therapy for the brain — the light form that is most important for brain health is near-infrared light. It's not visible to the eye, but we can feel it as a little bit of warmth, and it's an extremely powerful wavelength. Both red and near-infrared act in essentially the same way: they stimulate the electron transport chain to increase the production of cellular ATP. Where they differ is depth of penetration. Red light is quite superficial — a few millimeters. Near-infrared penetrates more deeply. When we look at the scientific research on supporting brain health, including for individuals with autism, pretty much exclusively we're seeing near-infrared light as the one that matters. Our products include both red and near-infrared intentionally. We have superficial blood vessels all around our head, and if you can get light as superficially and as deeply as possible, you're going to have the best outcome. For our head wrap, we use two forms of near-infrared light — one wavelength at 850 and another at 1050 nanometers — for broader coverage. Have you noticed anything else from Jordan's experience with red light therapy besides the stuttering improvement?

Rita: His days are very structured and it was very hard for him to accept changes in routine. That's decreased, which is great. His skin is also better — he had severe acne and that's improved. Jordan does have a language impairment and his processing speed is slower than most, and he acknowledges that. But he's at a point in his life where he just wants to continue to thrive. He's doing intensive work at the chiropractor doing reflex integration and body balancing as well. I would definitely say the red light therapy has helped. How is the light actually working at an intracellular level when we apply it to the head?

Genevieve: Great question. Red light therapy is unique as a non-pharmacological supportive tool that goes into your toolbox. It's not a drug intervention, not a medical device per se, but also not a lifestyle intervention. And it has an incredibly good safety profile — though with a caveat: if you're using a very high intensity device, the risk of increasing oxidative stress does increase. When you use a light therapy device — whether you're putting it on your head, chest, gut, or low back — the mechanism is the same. Depending on the wavelength, red or near-infrared, there is penetration and then absorption by a molecule called a photoreceptor. The red light is absorbed by photoreceptors more superficially in the skin. Near-infrared is absorbed by deeper photoreceptors. The target photoreceptor we want is the electron transport chain molecule called cytochrome C oxidase — complex four. Through that absorption, there is a release of nitric oxide, which is a tiny gas molecule that helps with blood flow. And ultimately through a cascade of downstream events, you have an increase in the synthesis of cellular energy. There's also another photoreceptor — water. Our cells are full of water, and this is a very underappreciated aspect of red light therapy that's really only starting to be recognized. Water absorbs near-infrared light and changes its structure, becoming slightly more viscous. When ATP is being synthesized in that mitochondria, that change in water viscosity actually helps in relation to the mitochondrial water. The main outcome — the umbrella effect — is an improvement in the metabolic health of the cell. This is why it's so relevant for people who have mitochondrial diseases or mitochondrial dysfunction: it helps support the production of cellular energy, which can restore some or all of that cellular function. And this is also why the lifestyle factors matter: if you're adding insults through diet or environmental toxins that are causing mitochondrial dysfunction, light therapy helps but it won't be the same as if you have that generalized mitochondrial support in place.

Genevieve: On the question of whether light is actually getting into the brain: if you take cadaver skulls and look at whether light actually penetrates through the hair and skull into the brain, you find that very little is penetrating. But then you look at the clinical literature and see that when light is applied to the head in a wide range of brain disorders — Alzheimer's, Parkinson's, depression, autism, ADHD — we see benefits. So the clinical benefits most likely aren't happening because of deep brain penetration. There are other things going on. A cadaver skull is not a fully functioning living system with blood flow, lymphatic flow, and energy transmission. And some of the studies on Alzheimer's and Parkinson's have applied light to the gut and found benefits to the brain — which speaks to the gut-brain axis. When I looked at the literature for autism, I found around four studies I consider reasonably well done. One is a standout because it was controlled, using a placebo device, comparing it to an actual light therapy device over eight weeks of transcranial photobiomodulation. The group that received actual near-infrared light therapy had statistically significant reductions in autism severity scores — a subjective measurement — but very importantly, they also found EEG changes. That's an objective result. The other studies, though not controlled, also found benefits. Animal model studies found objective measurements: decreases in oxidative stress and decreases in neuroinflammation. The limitation is that we don't have big studies with hundreds of subjects. But what we do have is a small number of studies including one that was very well controlled, animal studies, and both subjective and objective measurements with internal consistency. Because of that, and because of the incredible safety profile of red light therapy, I am very comfortable saying that applying light to the brain is something with really no downside. There's only upside.

Rita: I know that many chiropractors focus on red light therapy and some have a laser. Is that the same thing? Because a lot of families spend a lot of money on therapy and treatment, and if someone can save money and get a great product that they can use at home, I'd rather bring them that route.

Genevieve: A laser delivers a single wavelength of light at a very high intensity, which is why it's only used for a very short period of time. An LED light delivers a range of wavelengths. For example, our head wrap delivers three different wavelengths of light. One of them would be the 850 nanometer near-infrared, but it actually delivers a range of about 820 to 880 nanometers with 850 as the peak. That's the first difference: laser is a single wavelength, LED is a range. The second difference is intensity: the laser is extremely high intensity, the LED is low intensity. What happens in our body is that the body is interested in the dose of light — a function of treatment time and intensity. If we want to match a laser dose using an LED, we can — we just do the math. That's why our head wrap is meant to be used for 10 to 20 minutes while a laser is usually only 30 seconds. Can you get benefits from lasers? Absolutely. Can you get benefits from LED? Absolutely. So then it's a matter of weighing the other issues: going into a clinic versus doing it at home. That increased compliance with at-home use can actually make LED therapy superior because you can do it more frequently. And for somebody with a SOD2 polymorphism like Jordan, who's more sensitive to oxidative stress — the higher the intensity of the light, the greater the cellular stress, nudging up on that level at which you can tip the cell into increased oxidative stress. With LED devices, our wiggle room is much greater. We're much less likely to overdo it. After looking at this in depth, the answer has been clearly: no, we do not need lasers to get benefits. But there are benefits to both. It's really just up to people to decide what works best for their budget, lifestyle, and comfort.

Rita: If someone wants to purchase one, what would be a safe level and amount of time to start with?

Genevieve: The first thing to establish is the intensity of the device you're going to be using. At Fringe, we look to nature to guide our decision-making — we mirror the intensity of the sun, which is between 20 and 40 milliwatts per centimeter squared for those red and near-infrared rays. We do it for a longer period of time: for our head wrap, 20 minutes is our maximum, with some people choosing around 10 minutes. With people with autism, we have to be more intentional with the lead-in because of sensory issues — start low and slow. For someone who had an SOD2 gene polymorphism and was new to red light therapy, I would recommend starting at 5 minutes per day at 50% intensity. Our devices start at 100% intensity, but there's a button that reduces the intensity by 50%. Start there for a week, three to five times a week, monitoring for any adverse responses — no increase in hyperactivity, no headaches, no eye pain. These are very uncommon results, but it's always better to go slow rather than have to pull back afterwards. If they didn't have the SOD mutation, I would still start at five minutes but keep it at 100%, then over two weeks work up to 10 minutes, then 15 minutes, then ultimately 20 minutes if they're comfortable. Higher intensity devices — around 100 mW/cm² — typically you don't want to go above 10 minutes. There's also controversy over whether devices are actually as high intensity as they say, since there's a systemic issue in this market of using incorrect measurement tools to verify intensity. Make sure the device has third-party testing that validates the actual intensity. And for the brain, you don't want a red light only device — you want both red and near-infrared, or near-infrared only. We have two wavelengths of near-infrared and one red in our head wrap, with a ratio of one red to two near-infrared chips. Is it safe to do it every day at a lower intensity like Fringe devices? Yes. But almost all of the research in brain health uses a frequency lower than daily. Three to five times a week is what we recommend. The most important thing is consistency. Benefits have been observed using frequencies of two times a week all the way to seven times a week.

Rita: Can you speak to how we can use the Fringe head wrap for gut health?

Genevieve: The gut-brain axis is critical to the proper functioning of our brain — we talked about this so much at the beginning. There's an emerging area of research in this space. In humans, I haven't seen any studies with autism specifically, but I have seen studies with Alzheimer's, depression, and Parkinson's disease. The approach being taken is to target both the gut and the brain with light therapy. If you want penetration into the gut, you're going to need near-infrared light to get in deeper. There has been actual demonstration of changes in the gut microbiome towards a more favorable profile, as well as changes in the cognitive and behavioral outcomes being measured. We designed our head wrap so that it can be used on both areas. It opens up and can be laid flat, fitting very nicely along the gut — it covers both the upper and lower abdomen. In terms of protocols: this is one where people often prefer to alternate days rather than treat both areas in the same day. A very easy approach: one day you treat the head, the next day you treat the gut, and take one day off a week. That gets you at three times a week for each area. For the gut with children, it's a great opportunity during quiet time when they're sitting and maybe on their iPad — just put it on there and secure it with a Velcro strap around the waist. One of the things that's notable in this gut research is that you're seeing effects not just on the microbiome but on the human host as well. The light is getting in and benefiting two organisms: all of the bacterial species and also the human gut tissue itself. There's a lot of potential for benefit here, especially for our kids with autism and ADHD.

Rita: This is not just limited to children with complex needs like those diagnosed with autism or ADHD. This really benefits everyone in the family, just like nutrition and lifestyle is for everyone.

Genevieve: I agree completely. There was even a study recently published looking at using red light therapy at the family level, with children and parents both using devices and reporting the different benefits observed. These devices can be shared across family members. Our head wrap is adjustable — it fits on tiny heads and bigger heads. It accommodates different people across the age span and different genders. I use the head wrap on a regular basis for cognitive health. There have been nine studies published to date on using transcranial photobiomodulation in people who are generally of healthy cognition, which are the hardest to find benefits in. It's remarkable that in healthy adults, applying red light therapy to the head has improved aspects of cognition including memory. I usually do it three times a week. It also helps support hair growth, which can be great for menopausal women and men as well. Very diverse benefits. Thank you so much Rita. Where can people find you?

Rita: They can find me on Instagram — my handle is Rita underscore purely functional nutrition. That's the best way to find me. I also have a website, purelyFunctionalNutrition, but I share most of my information on Instagram. If anyone wants to schedule a call with me, there's a link in my bio. Anyone can send me a DM or an email — I'm always quick to respond. My hope for every family I connect with is to leave them with clarity on how to move forward.

Genevieve: Amazing. Thank you so much for being here, and thanks to everybody for listening. Please join us next time.

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Last updated: June 24, 2026
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about the author

Dr. Genevieve Newton, DC, PhD

Gen spent close to 20 years as a researcher and educator in the field of nutritional sciences before joining Fringe as its Scientific Director. Gen’s job is to “bring the science” that supports Fringe’s products and education. She is passionate about all things Fringe, and is a deep believer in healing body, mind and spirit using the gifts of the natural world.

The contents in this blog; such as text, content, graphics are intended for educational purposes only. The Content is not intended to substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your healthcare provider.